Location: US-221 and Island Ford Rd, Cherokee Cty Welcome to South Carolina! 221 continues across the state on its way to Florida. Location: US-221 and Rd S-11-146, Cherokee Cty About a mile later, as we approach Chesnee, turn left to follow a local road to US-221 Alternate. Location: US-221 and Rd S-11-146, Cherokee Cty Turn … Continue reading U.S. Route 221, NC State Line to US-221 Alt/SC-11